4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride
4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate,hydrochloride
CAS: 24735-18-0
Molecular Formula: C14H22ClN3O5
4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride - Names and Identifiers
4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride - Physico-chemical Properties
| Molecular Formula | C14H22ClN3O5 |
| Molar Mass | 347.79458 |
| Melting Point | 194℃ |
| Storage Condition | Sealed in dry,Room Temperature |
| MDL | MFCD09953249 |
| Physical and Chemical Properties | White crystalline powder, soluble in methanol and water, derived from motherwort Leonurus artemisia (Laur.) S. Y. Hu F. |
| In vitro study | Leonurine (0, 5, 10, 20, 40, 80 µM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24 h. Leonurine hydrochloride (125, 250, 500 μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20 µM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner. |
| In vivo study | Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20 mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model. |
4-Guanidinobutyl 4-hydroxy-3,5-diMethoxybenzoate hydrochloride - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.875 ml | 14.376 ml | 28.752 ml |
| 5 mM | 0.575 ml | 2.875 ml | 5.75 ml |
| 10 mM | 0.288 ml | 1.438 ml | 2.875 ml |
| 5 mM | 0.058 ml | 0.288 ml | 0.575 ml |
Last Update：2024-01-02 23:10:35
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Product Name: 4-(diaminomethylideneamino)butyl 4-hydroxy-3,5-dimethoxybenzoate,hydrochloride Visit Supplier Webpage Request for quotation
CAS: 24735-18-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 24735-18-0
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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